It is significant for its association with George Hoyt Whipple (1878–1976), a Nobel Prize-winning doctor and pathologist who was born here.

[2] Whipple gave the house to the town in 1970, and it is now operated by the Ashland Historical Society as a museum, open during the warmer months.

It is a 1½-story brick building, with a gabled roof, two end chimneys, and a wood-frame ell to the rear.

Its front facade is five bays wide, with sash windows arranged symmetrically around the center entrance, and a pair of gabled two-window dormers in the roof face.

It is here that George Hoyt Whipple was born in 1878, and the house remained in the family until he donated it to the town for use as a museum.