The white-tipped tufted-tailed rat (Eliurus penicillatus) is a rodent endemic to Madagascar.

It is listed by the International Union for Conservation of Nature (IUCN) as an endangered species due to habitat loss.

It has been considered to be a specimen of Major's tufted-tailed rat (Eliurus majori) but new information confirmed the original identification.

The first was collected in 1895 or 1896 from the Ampitambe forest, near Ambositra in Fianarantsoa Province and a second 35 km (21.7 mi) north-east of Fandriana in the Fandriana–Marolambo corridor in 2000.

It is thought that it could be threatened by the fragmentation of its humid forest habitat to cultivated land, and it is possible that all species of the subfamily Nesomyinae suffer from a plague carried by introduced rodents.