[3] Originating on the slopes of Mount Adams, it flows into the Columbia Gorge near the community of Underwood.

The principal tributaries of the White Salmon River include Trout Lake and Buck, Mill, Dry, Gilmer, and Rattlesnake Creeks.

In 2005, the upper river between the headwaters and the boundary of the Gifford Pinchot National Forest was added to the designation.

A popular spot to launch a raft or kayak is the public put-in at the unincorporated community of BZ Corner.

Guided whitewater trips can be arranged with commercial outfitters with special-use permits for the White Salmon.