The music video for the single features the group rapping in a Cadillac Escalade and driving around Memphis, as each member is introduced along with their respective verse.
Juicy J states that the group was "high as hell" during filming, and feared that he would fall off of the car.
[3] On March 16, 2018, G Herbo made an appearance on the K-104 radio station, and freestyled over the "Who Run It" instrumental.
The freestyle soon went viral, and G Herbo released a full remix of the song on March 22, at the request of Drake.
[4] It has since inspired a popular freestyle challenge, spawning remixes from several rappers including ASAP Rocky, 21 Savage, Chief Keef, Cupcakke, Dave East, Lil Uzi Vert, Lil Yachty, Trippie Redd, and Young M.A.