A duet version of the song featuring vocals from Jennifer Nettles of the American duo Sugarland was also shipped to country music radio.

"Who Says You Can't Go Home" was released as the second single in North America in March 2006 and reached the top 30 on the US Billboard Hot 100, peaking at number 23.

In the United States, a version of the song was released to the country music format as a duet with Jennifer Nettles, lead singer of the duo Sugarland.

After Jon Bon Jovi decided that Urban's voice was too similar to his own, he asked a representative of Mercury Records to recommend a female duet partner.

[6] The shooting of the music video for the regular version, featuring a man dressed up as a dog, began at the March 9, 2006 Bon Jovi concert at the Glendale Arena outside Phoenix and continued in the Los Angeles area.