The name of the comedy duo Yoiko is written yowiko ("よゐこ"), 2 characters in the video game series Touhou Project have "ゐ" in their names: Tewi Inaba (因幡　てゐ (Inaba Tewi)) and Tenshi Hinanawi (比那名居　天子 (Hinanawi Tenshi)), and the first opening theme to the Future Diary anime series is titled "空想メソロギヰ" (Kuusou Mesorogiwi).

In the mid-to-late 11th century, the Iroha song was developed, and い, え, and お (i, e, and o) were differentiated from ゐ, ゑ, and を (wi, we, and wo).

In the Gojūon ordering (developed around 1075 by the scholar Hirotomo, based on the Siddhaṃ script), there were no sounds for “yi”, “ye”, “wu”, or “wo”.

Since the Nara period, /h/ began to be pronounced as [w] in word-medial position; by the beginning of the 11th century, this phenomenon, called the "Ha-line shift", had become more widespread.

At the end of the 12th century, the literary work “Shinkyō Shiki Chū” (which contained katakana, from the last years of the Insei period) attests examples of ゐ and い losing their distinction, such as “率て” (wite) being written “イテ” (ite).

Fujiwara no Teika (1162–1241), in the “Unpleasant Characters” (嫌文字事) section of Gekanshū (a poetry volume), established rules for about 60 words containing を/お, え/へ/ゑ, and い/ひ/ゐ, based on a number of writings from the mid-11th to 12th century.

Teika's syllabary particularly drew from poetry such as waka and renga, but a number of examples of confusion between い, ゐ, and word-medial/final ひ were also frequently pulled from other sources.

In the Nanboku-chō period, the scholar Gyōa published the Kanamojizukai (Kana Character Syllabary, completed in 1363), drastically augmenting the lexicon by over 1000 words.