The House of Wickersham, also known as the Wickersham State Historic Site, is a historic house at 213 7th Street in the Chicken Ridge area of Juneau, Alaska, United States.

It is a historic house museum operated by the state of Alaska, memorializing the life of James Wickersham (1857-1939), an influential political leader in Alaska in the early 20th century.

The house, a 2+1⁄2-story frame structure, was built in 1899 by Frank Hammond, owner of a mining company.

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