The Wicomico River (/waɪˈkɒmɪkoʊ/ wy-KOM-ik-oh) is a 24.4-mile-long (39.3 km)[1] tributary of the Chesapeake Bay on the eastern shore of Maryland.

Barge traffic on the river has made Salisbury the primary shipping point for goods on the Delmarva Peninsula over the last several centuries.

A civic group, the Wicomico Creekwatchers, have been testing water quality at 22 different points along the river since 2002.

[3] Their 2016 report, released in April 2017, showed that the water quality decreased compared to 2015, with higher levels of phosphorus, nitrogen, and bacteria.

[4][5][6] The name Wicomico derives from the Nanticoke words wicko mekee, meaning "a place where houses are built," referring to a Native American village on the banks.