originally aired on Fox from September 30, 2007, to May 18, 2008, and consisted of sixteen episodes.

The first half of the season is included within the Volume Three DVD box set, which was released on April 15, 2008, and the second half is included within the Volume Four DVD box set, which was released on April 28, 2009.

He was later replaced by Joel McNeely, who frequently collaborated with MacFarlane and worked on the series' musical score, along with Walter Murphy, ever since.

Because of the 2007–2008 Writers Guild of America strike, there was a shortage of episodes this season.

Much like season 6 of Family Guy, the episodes that were shown during the WGA strike were done so without permission from Seth MacFarlane, since MacFarlane showed support for the writers by not finishing any planned episodes until the strike ended.