With the Gastonia Honey Hunters winning both halves, the Genomes' 67–65 overall record saw them finish four games behind the Rockers for the wild card spot.
Following the season, the Genomes' spot in the league was purchased by Attain Sports and Entertainment, owners of the Bowie Baysox and Frederick Keys.
The new Spire City Ghost Hounds began to play at Nymeo Field at Harry Grove Stadium, home of the Keys, in 2023.
[6] The Wild Health Genomes franchise played one season in the Atlantic League of Professional Baseball (2022).
One notable roster member was Khris Davis, playing in his final professional season after leading the majors in home runs in 2018.