The history of Wildersgade dates back to the foundation of Christianshavn as an independent market town in 1617–22.

The section to the north of Torvegade was known as Store Kongensgade (Great King's Street) while the section to the south of Torvegade was called Lille Kongensgade (Little King's Street).

Its name was later changed to Vestre Borgerdyd School and it is now called Københavns Åbne Gymnasium.

The main building was built by Jørgen Henrich Rawert and Andreas Hallander in 1802.

The large, neighbouring building (Overgaden Neden Vandet 9) is a former engine hall from the 1860s and was also built for B&W.

The two white buildings at the southern end of the street were built in 1998–2001 as part of Henning Larsen Architects¨Christiansbro masterplan for the redevelopment of the B&W site.

They are called Løvens Hård and Enhjørningens Gård and were designed by Lauritz Vilhelmsen Arkitekter and Arkitema.

Listed buildings along this southern portion of the street includes the narrow townhouses at No.

In the 2009 film Applause Café Eiffel (Wildersgade 58) is the place where Thea Barfoed (Paprika Steen) goes to get drunk.

[2] Another bar, Fingerbøllet (Wildersgade 39), was used as a location in Anders Thomas Jensens Blinkende Lygter (2000) and Nikolaj Arcel's Kongekabale (2004) as well as in the DR television series Taxa.