The firm operates in industries including energy, manufacturing, defense, aerospace, intelligence, information technology, professional services, telecommunications, health care, architectural and engineering (A&E), and construction.

With Fielding's return to the White House as Counsel to President George W. Bush on February 1, 2007, the firm reverted to the name Wiley Rein LLP.

Peter Zeughauser stated in The Wall Street Journal that "it's troubling, and it's inappropriate" that large law firms took the loans, comparing it to other firms where partners reduced their pay; WSJ noted Rein and others have average partner profits above $1.2 million per year and make over $100 million per year.

[citation needed] Wiley is recognized for its service to the local community and pro bono efforts,[13] including negotiating a landmark health-care-related settlement on behalf of inmates at a Virginia women's prison,[14] a settlement with the Baltimore Police Department in a civil rights case, and teaching high school students at the Academies at Anacostia.

[16] Wiley is regularly ranked among the top ten in Washington Business Journal's Corporate Philanthropy List (Midsize Companies by Giving in Greater D.C.).