In February 1983, Scypion beat Frank Fletcher by a twelve round decision to take the USBA's regional Middleweight title.
This victory guaranteed him a world championship fight, against Marvelous Marvin Hagler.
Scypion was knocked out in the fourth round in his only world title attempt, which was held in Providence, Rhode Island.
It was the first bout to simultaneously decide the WBA, WBC and IBF titles in history.
In the ninth round of a bout at Madison Square Garden on November 23, 1979, Scypion made his 13th knockout in 13 pro fights, but inadvertently caused the fatal injury of Willie Classen, who died five days later without having regained consciousness.