Wilkes is the northeasternmost neighborhood in Portland, Oregon, bordered on the north by the Columbia River and on the east by the city of Gresham, where it expands into the city as the neighborhood of Wilkes East.

It adjoins the neighborhoods of Argay, Russell, and Hazelwood on the west, and Glenfair on the south.

Wilkes is a mostly suburban and residential neighborhood in the south, but has many business parks and industrial space north of Sandy Boulevard.

[5] Since then, the city's parks department and its Bureau of Environmental Services partnered to acquire 20 acres (8.1 ha) of land at the headwaters of Wilkes Creek in March 2011 to create a second park and natural preservation area.

This Multnomah County, Oregon state location article is a stub.