Wilkesboro is an unincorporated community in Washington County, Oregon, United States.

[2][3] The locale was named about the time United Railways built its interurban line through the area.

[2][3] In 1915 the town had a population of 50, two churches, a fraternal lodge, a farmer's alliance and a railroad depot.

[6] The GC&WR also connected with the Tillamook Branch of the Southern Pacific line in Wilkesboro—that line is now operated by the Portland and Western Railroad[6] via a lease agreement with the Port of Tillamook Bay Railroad.

When Oregon Route 6 was extended from Glenwood in 1957, portions of it used the then-abandoned GC&WR grade.