Wilkesboro-Smithey Hotel, also known as the Smithey Hotel or Smithey's Department Store, is a historic hotel building located at Wilkesboro, Wilkes County, North Carolina.

It was built in 1891, and is a three-story, nine bay by six bay, brick building.

It features a two-story wraparound gallery porch.

[2] It was listed on the National Register of Historic Places in 1982.

[1] This article about a property in Wilkes County, North Carolina on the National Register of Historic Places is a stub.