Wilkesville is a village in Vinton County, Ohio, United States.

[5] According to the United States Census Bureau, the village has a total area of 0.29 square miles (0.75 km2), all land.

36.2% of all households were made up of individuals, and 11.5% had someone living alone who was 65 years of age or older.

The racial makeup of the village was 95.36% White, 2.65% Native American, and 1.99% from two or more races.

40.0% of all households were made up of individuals, and 21.4% had someone living alone who was 65 years of age or older.

There were 16.7% of families and 18.8% of the population living below the poverty line, including 16.0% of under eighteens and 27.6% of those over 64.