The Will Marion Cook House is a historic townhouse at 221 West 138th Street, in the part of Harlem known as Strivers' Row in Manhattan, New York City.

This area, known as Strivers' Row, was home to a number of well-known people during the height of Harlem's cultural successes of the early 20th century.

It is an end unit of a row of sixteen three-story Renaissance Revival brick rowhouses, built by developer David H. King in 1891.

He was an early innovator in the use of musical improvisation, helping give rise to jazz and the Big Band Era.

Cook was a mentor and influence on Eubie Blake and Duke Ellington, and helped further the career of his wife, soprano Abbie Mitchell.