He is notable for his five seasons as a cast member on Mad TV from 1997 to 2002, for starring as Curly in the 2012 film reboot of The Three Stooges, and as Mover #1 in Happy Gilmore (1996).

Andrew "Andy" Pepper in Mom (2013–2021), Ben Burns in Loudermilk (2017–2020), Bill Ryan in United We Fall (2020), and Jim McAllister in Young Sheldon (2022–2024) and Georgie & Mandy's First Marriage (2024–present).

[3] By the end of its second season (1996–1997), the Fox network sketch comedy television series MADtv experienced its first big cast turnover.

[4] After leaving MADtv, Sasso's television appearances included four seasons as Carl Monari on Less than Perfect, as well as a role in Robson Arms.

[11] In 2012, Sasso created the Ten Minute Podcast, which he hosted originally with Bryan Callen and Chris D'Elia, later replaced by Tommy Blacha and Chad Kultgen.