Willem Frederik Hesselink (8 February 1878 – 1 December 1973) was a Dutch football player and one of the founders of local club Vitesse in 1892.

In 1900, Hesselink was a member of the HVV side that participated in the first edition of the Coupe Van der Straeten Ponthoz, regarded by many as the first-ever European club trophy.

In January 1906 Hesselink left Munich, leaving a club that had grown considerably in his time at the helm in the hands of Kurt Müller, and returned to the Netherlands.

Over the years Hesselink built up a colourful curriculum vitae including doctorates in chemistry and philosophy, becoming director of the Keuringsdienst van Waren, being expert witness in several murder trials, founding a laboratory, and writing several health books.

His thesis on the secrets of Port wine made on the banks of the Douro has proved to stand the tests of time and is still quoted regularly.