[1][3] He was a pastor at Powhatan Point, Ohio (1885–1896), Moundsville, West Virginia (1896–1901) and Philadelphia, Pennsylvania (1908).

[2] His son Frank Harry Mead Williams (1896–1972) was a math professor at Drexel University.

[2][5] Williams was a Christian young earth creationist who claimed to have mathematically disproven evolution.

[10] Williams' book gave the first presentation of the creationist probability argument against evolution which influenced the pseudoscientific creation science movement.

[6][11] Glenn Branch deputy director of the National Center for Science Education has described Williams' arguments against evolution as "pseudomathematics".