William Apollos James House is a historic home located at Bishopville, Lee County, South Carolina.

It was enlarged and altered in 1911, in the Colonial Revival style, with the addition of a second story with hipped roof, and a hip-roofed wraparound porch.

It was the home of William Apollos James (1857–1930), prominent state representative, agriculturalist, businessman, and community leader of Lee County.

Also on the property is a collection of historic and interesting flora in its ornamental and fruit garden, along with mature trees and shrubs.

This article about a property in Lee County, South Carolina on the National Register of Historic Places is a stub.