[1] He was raised and educated in Moretown, and was an 1874 graduate of the Vermont State Normal School in Randolph.

[1] He then began attendance at the Homeopathic Medical College of the State of New York, from which he graduated as a Doctor of Medicine in 1877.

[1] Mayo was a member of the Alpha Sigma Pi fraternity and an officer of the Vermont Medical Society.

[1] In 1888, he was the party's unsuccessful nominee for secretary of state, losing the general election to incumbent Charles W.

[1][2] Mayo was the Democratic nominee in the 1922 United States Senate election, and lost to U.S. Representative Frank L.

[4] Mayo Healthcare is a Northfield senior citizens' residential and health care facility.

[8][9] Mayo and his second wife were the parents of daughters Anna and Deborah and sons William Thomas, and Edgar.