[5] Spofford was ordained deacon in November 1944 and priest on June 23, 1945 at the Church of the Good Shepherd in Boston by Bishop William Appleton Lawrence of Western Massachusetts.
[7] He then served as Executive Secretary of the Episcopal League for Social Action between 1946 and 1949 and as rector of St Thomas Church in Detroit from 1947 until 1950.
He held the latter post until 1956 when he was appointed chief of chaplain at the Massachusetts General Hospital.
During his episcopacy the missionary district became a diocese and thus he became the first diocesan bishop of Eastern Oregon in 1971.
[10] He retired in 1979 and then served as Assistant Bishop in the Episcopal Diocese of Washington until 1984, and then briefly again in 1990.