William C. Grimes (November 6, 1857 – April 8, 1931) was an American politician and businessman who had a major influence on Oklahoma politics.

He went into real estate, enlarged his farm, built business blocks and residential areas in town, and helped to establish Kingfisher College (active from 1895 to 1922).

During his career as marshal, which lasted until 1893, he established a sound mechanism for the enforcement of federal law.

[2] In 1901, William M. Jenkins was not reappointed Governor of Oklahoma Territory due to a major scandal over a state contract.

Although Grimes was accused of involvement in the suspect transaction, he continued to serve in the administration of Thompson Benton Ferguson until January 1906.