William Case (August 10, 1818 – April 19, 1862) was an American politician of the Whig Party and served as the 12th mayor of Cleveland, Ohio from 1850 and 1851.

[1] He also served as president of the Cleveland, Ashtabula, and Painesville Railroad and secured the funding to finish its Chicago-to-Buffalo route.

In 1850, Case was elected mayor of Cleveland as part of a "Rail Road Ticket" of Whig candidates who disfavored disturbing the location of the terminus of the Cleveland, Columbus and Cincinnati Railroad, defeating Democratic candidate and former City Council president Benjamin Harrington.

In 1851, he was re-elected for another one-year mayoral term as part of a "Citizen's Ticket" of Whigs and Free Soilers, defeating challenger Robert Parks.

"[1] He is often credited with establishing the Cleveland nickname, "The Forest City", as a result of a citywide fruit-tree planting campaign.