William Chambers Coker (October 24, 1872 – June 26, 1953) was an American botanist and mycologist.
He graduated from South Carolina College in 1894 and took postgraduate courses at Johns Hopkins University and in Germany.
He taught for several years in the summer schools of the Brooklyn Institute of Arts and Sciences, at Cold Spring Harbor, L. I., and in 1902 became associate professor of botany at the University of North Carolina.
In 1903, he was chief of the botanic staff of the Bahama Expedition of the Geographical Society of Baltimore.
Professor Coker was a member of many scientific societies and the author of The Plant Life of Hartsville, S. C. (1912); The Trees of North Carolina (with Henry Roland Totten) (1916); and The Saprolegniaceae of the United States (1921).