[1] On 16 September 1816, Macready made his first London appearance at Covent Garden as Orestes in The Distressed Mother, a translation of Racine's Andromaque by Ambrose Philips.

Transferring his services to Drury Lane, he gradually rose in public favour, his most conspicuous success being in the title role of Sheridan Knowles's William Tell (11 May 1825).

[citation needed] Already, Macready had done something to encourage the creation of a modern English drama, and after entering on the management of Covent Garden in 1837 he introduced Robert Browning's Strafford, and in the following year Bulwer-Lytton's The Lady of Lyons and Richelieu, the principal characters in which were among his most effective parts.

On 10 June 1838, he gave a memorable performance of Henry V, for which Stanfield prepared sketches, and the mounting was superintended by Bulwer-Lytton, Dickens, Forster, Maclise, W. J.

[1] Dickens wrote to him in 1847: "The multitude of tokens by which I know you for a great man, the swelling within me of my love for you, the pride I have in you, the majestic reflection I see in you of the passions and affections that make up our mystery, throw me into a strange kind of transport that has no expression but in a mute sense of an attachment which in truth and fervency is worthy of its subject.

"[5] The first production of Bulwer-Lytton's Money took place under the artistic direction of Count d'Orsay on 8 December 1840, Macready winning unmistakable success in the character of Alfred Evelyn.

Both in his management of Covent Garden, which he resigned in 1839, and of Drury Lane, which he held from 1841 to 1843, he found his designs for the elevation of the stage frustrated by the absence of adequate public support.

In 1843–44, he made a successful tour in the United States, but his last visit to that country, in 1849, was marred by the Astor Place Riot, in which between 22 and 31 rioters were dead, and more than 120 people injured.

According to the Encyclopædia Britannica Eleventh Edition: Macready's performances always displayed fine artistic perceptions developed to a high degree of perfection by very comprehensive culture, and even his least successful personations had the interest resulting from thorough intellectual study.

With the exception of a voice of good compass and capable of very varied expression, Macready had no especial physical gifts for acting, but the defects of his face and figure cannot be said to have materially affected his success.