Constructed in the final quarter of the nineteenth century, it was once the home of one of the village's premier businessmen, and it has been named a historic site.

Upon moving to Mechanicsburg in 1853, he worked as a journeyman for three years before beginning his own carriage manufacturing business in 1856 with Cyrus Barr.

Their partnership was highly successful; by 1880, Culbertson and Barr had developed a reputation as one of the region's premier manufacturers of carriages, buggies, and spring wagons, as well as operating a livery from 1860 to 1874 and remaining a well-reputed repair center.

[5]: 6 Built of brick on a stone foundation,[6] the William Culbertson House is a two-story building with a hip roof.

Numerous elements combine to make it a typical example of the Italianate style, including its irregular floor plan with a large bay that projects eastward from the main body of the house, a cornice formed by ornamental brackets, a decorative front porch, and hood molds over the windows.