[3] He moved with his family to suburban Cleveland, Ohio in 1980, when his father became the chairman of the Department of Neurology at Case Western Reserve University.

He also studied at Kraków, Poland's Jagiellonian University, where he received a certificate in the history of Eastern European Jewry and The Holocaust.

[5][6] William Daroff worked on three presidential campaign staffs: Rep. Jack Kemp in 1986–88, then-Vice President George H. W. Bush in 1988, and Sen. Bob Dole in 1996.

He was also involved in the Jewish Community Federation of Greater Cleveland, serving on the board of its Young Leadership Division, the community relations committee, the advocacy task force, the Young Adult Initiative board, and the public education initiative.

[10] President George W. Bush appointed Daroff to serve on the honorary delegation to accompany him to Jerusalem for the celebration of the 60th anniversary of the State of Israel in May 2008.

[23] He has also been widely quoted in leading news outlets, including The New York Times,[24] The Washington Post,[25] USA Today,[26] The Los Angeles Times,[27] Newsweek,[28] The International Herald-Tribune, Slate,[16] The Jerusalem Post,[29] Ha’aretz, The Jewish Telegraphic Agency (JTA), The Jewish Daily Forward,[30] and newspapers around the world.