Business interests outside baseball include Reynolds, DeWitt & Co., which owns Arby's franchises and invests in the U.S.

On August 19, 1951, the little person Eddie Gaedel served as a pinch hitter at a Browns game, wearing DeWitt's jersey to the plate.

[2] DeWitt was part of an investment group led by Francis L. Dale that purchased the Cincinnati Reds for $8 million from his father, Bill Sr., on December 5, 1966.

When Eddie Chiles prepared to sell the Texas Rangers baseball franchise in 1989, DeWitt and Bush gathered investors to buy the team.

[2] DeWitt was part owner of the Riverfront Coliseum in Cincinnati on December 3, 1979, when 11 people were killed prior to a concert by The Who.

[2] Since DeWitt bought the team, the Cardinals have won two World Series (2006 and 2011), four National League pennants, 11 division titles, and have made 15 total playoff appearances.

[11] Since 2004, the organization has run Redbird Rookies, a network of 20 leagues for nearly 4,500 children around Greater St. Louis and in rural sections of Missouri and Illinois.

[15] To expand the Cardinals' international presence, DeWitt opened baseball academies in the Dominican Republic and placed representatives in six foreign countries.

[17] Busch Stadium cost $45 million (12%) in a long-term loan from St. Louis County, while, by comparison the Milwaukee Brewers' American Family Field ended up drawing 77.5% in public funding.

DeWitt began emphasizing developing talent as much as possible through the minor leagues, rather than relying mainly on free agents.

[21] The Cardinals also announced the rechristening of the team Hall of Fame Museum, with an annual selection process commencing in 2015.

Closed since 2008, when the International Bowling Hall of Fame moved to Texas, this reincarnation of the museum is located in the newly constructed Ballpark Village within the same building as the Cardinal Nation Restaurant.

It was regarded as the first known case of corporate espionage involving computer network hacking in professional sports.