William E. Wheeler House is a historic home located at Portville in Cattaraugus County, New York.

It is a 2+1⁄2-story Stick-style wood-frame dwelling built in 1880.

Also on the property is a contributing carriage house.

[2] It was listed on the National Register of Historic Places in 2002.

This article about a historic property or district in Cattaraugus County, New York, that is listed on the National Register of Historic Places, is a stub.