William Osborne Goode (September 16, 1798 – July 3, 1859) was an American politician, slave owner, and lawyer from Virginia.

Admitted to the Virginia bar in 1821, William Goode set up a legal practice in Boydton, the Mecklenburg county seat.

As a legislator, Goode had opposed making manumission of slaves easier, as advocated by Thomas Jefferson Randolph.

In 1829, William Goode married the widow Sarah Maria Waller Massie (1812-1844), who had already born children and bore several more children who lived to adulthood during this marriage, although she also died shortly after childbirth, and that daughter Sarah Massie Goode (1844-1847) died as a child.

Three of their sons became Confederate States Army officers after their father's death and Virginia's secession, of whom William Osborne Goode Jr. (1830-1865) died in battle.

Their son Edward Branch Goode (1839-1920) would also become a Confederate officer (in the 34th Virginia Infantry) and survive the war.