William Grahame (1808 – 26 November 1890) was an Australian politician.
He was also a life member of the New South Wales Legislative Council from 1875 until 1889.
Grahame was born in Stirlingshire, Scotland and migrated to Australia in 1828.
He initially worked as a sheep hauler but rapidly acquired a large amount of land in the Monaro area.
He failed in an attempt to win the seat of Monaro at the 1864–65 election but was elected to parliament unopposed at a subsequent by-election when it was found that the winner of the seat, the Premier, James Martin, had been elected to two seats.