The William H. McGuffey Boyhood Home Site is a National Historic Landmark in Mahoning County, Ohio.

The site, now a regional park known as the McGuffey Wildlife Preserve, was designated a National Historic Landmark in 1966.

The parcel is basically flat, with a low ridge running north-south in its eastern part.

McGuffey was a prominent proponent of public school education, and taught at Miami University for many years.

[3] The 73-acre property of the McGuffey homestead that has survived subdivision was acquired by a nonprofit organization around the time it was designated a National Historic Landmark in 1966,[3] and was donated to the county for use as a nature preserve in 1998.