William Henry McKeighan (July 1, 1886 – September 15, 1957) was a Michigan politician and state political boss based in Flint.

McKeighan established a "base of operations at Leith Street and Industrial Avenue" where he owned a barber shop and pool hall, then organized his political machine.

His first time was in 1915 for a single 1-year term then again in 1922[3] defeating Marvin C. Barney, Citizens Party candidate.

So, he ran the "Green Slate" of candidates who won in 1931 and 1932 that[2] he was selected Flint Mayor in 1931 by the other City Commissioners.

Along with his political ally, Frank D. McKay, McKeighan was charged with conspiracy to violate state liquor laws in 1945; he was given a judge-directed verdict of not guilty.