William Henry Stafford (October 12, 1869 – April 22, 1957) was a U.S. Republican politician from Wisconsin.

He was an unsuccessful candidate for renomination in 1910, but the eventual nominee lost the general election to Socialist Victor L. Berger.

Berger defeated him in the 1918 election, but Congress refused to seat him because he had been convicted for violating the Espionage Act.

Berger won the ensuing special election, but Congress again refused to seat him.

He was an unsuccessful candidate for renomination in 1932 and for the Republican nomination for the United States Senate from Wisconsin in 1938.