William Hardy Murfree (October 2, 1781 – January 19, 1827), born in Hertford County, North Carolina, was a member of the United States House of Representatives from North Carolina.
He graduated in 1801 from the University of North Carolina at Chapel Hill where he studied law.
He served as Chairman of the Committee on Public Expenditures in the Fourteenth Congress.
In 1823, he moved from Murfreesboro, North Carolina, to his estate in Williamson County, Tennessee where he died on January 19, 1827.
His home at Murfreesboro, North Carolina, Melrose, was listed on the National Register of Historic Places in 1971.