He began his education at Merchant Taylors' School, London, on 12 September 1701 and went up to St John's College, Oxford, on 11 June 1707, matriculating on 2 July.
Holmes was Vice-Chancellor of Oxford University between 1732 and 1735,[1][2] and in this post, was appealed to by John Wesley about the concerns of the critics of the Holy Club.
Holmes was supportive of sound learning and met with Thomas Hearne, who wished the University to plan the printing of Oxford manuscripts.
However, his allowing Handel to perform inside the Sheldonian Theatre on several occasions outside of University ceremonies and to charge 5 shillings.
Only one work is ascribed to Holmes, The Country Parson's Advice to his Parishioners … of the Younger Sort, which was an anonymous publication of 1742.