William Hooper School is a historic school building located on Mears Street between South 4th and South 5th Streets in Wilmington, New Hanover County, North Carolina.

It was designed by Joseph F. Leitner's firm and is described as being in a Classical Revival style.

The school closed in 1984 and in 1998 the building was converted to apartments for the elderly.

It is named for William Hooper (1742-1790) of Boston, Massachusetts, who was a representative of North Carolina and signed the Declaration of Independence.

This article about a property in New Hanover County, North Carolina on the National Register of Historic Places is a stub.