William I, the One-Eyed (19 December 1343, Dresden – 9 February 1407, Schloss Grimma) was Margrave of Meissen.

His nickname is related to the legend that Saint Benno appeared to him because of his disputes with the Church in a dream and he had an eye gouged out.

After his brother Frederick III died 1381, he performed in 1382 with the remaining heirs so-called Division of Chemnitz, in which he was awarded the Margraviate of Meissen for an inheritance.

Since 1395 he managed as governor (vicarius) Jobst of Moravia (his brother in law) and the March of Brandenburg.

William was one of the most active Wettin princes, worked cleverly to the removal of powers of small noble-free estates in the interior of Meissen and the defence of the Bohemian House of Luxembourg.