[3] Built in 1902–1903, it is noteworthy as the home of politician William Jennings Bryan (1860–1925), and was declared a National Historic Landmark in 1963.

The house is a brick building, 1+1⁄2 stories in height, with a combination of Classical Revival and Queen Anne Victorian styling.

It has the varied rooflines typical of the latter style, including a two-story square turret at the right front corner, topped by a slightly bellcast pyramidal roof with flared edges.

He was three times an unsuccessful candidate for President of the United States (in 1896, 1900, and 1908), and gave the influential Cross of Gold speech to the 1896 Democratic Party Convention.

Although the building remains in the hospital's ownership, it was restored in 1961 to the period of Bryan's occupancy, and opened as a museum operated by the state historical society and the local Junior League.