As one of Henry's chaplains and clerk of the closet he was at the Field of the Cloth of Gold in 1520; and seems to have been made prebendary of Llanvair in Bangor Cathedral in the same year.
[3] On 10 June 1520 he was commissioned, with Sir Thomas More, John Hussee, and Hewester, to settle the disputes between the English merchants and the Teutonic Hanse, and went again to the Netherlands.
Knight made a journey on diplomatic business into Switzerland in 1522; went on an embassy to the empire respecting the wool staple, and was (11 November) admitted archdeacon of Chester.
[3] In 1527, though he complained that he was old and losing his sight, Henry decided to send him to Rome to promote his divorce; Thomas Wolsey thought Jerome de Ghinucci, bishop of Worcester, would have been better suited to the work.
On 10 September Knight saw Wolsey at Compiègne, and at his directions went on to Venice to watch for an opportunity to get access to the captive Pope Clement VII.
He managed to get a safe-conduct through Gambara the prothonotary, but was nearly murdered at Monterotundo (4 December 1527), and when he entered Rome all he could do was to send in his letters of credence with a note of what the king wished.
By the end of December, Henry Jerningham wrote that the secret of Knight's negotiation had not been well kept, and that the Emperor had written to the pope accordingly.
[3] He went (13 December 1528) on another mission with William Benet to Anne de Montmorency, to confer about Italian affairs, and was instructed to proceed on again to Rome.
[3] [5] In February 1532 Hacket and Knight were appointed to treat with the emperor's commissioners about commerce; the embassy did not bear much fruit.
He died in 1547 at Wiveliscombe, Somerset, and was buried in Wells Cathedral next to Sugar's Chapel, where a pulpit which he had erected and which bears his arms served as a monument.
When in London Knight lived in a house in Cannon Row, Westminster, afterwards (1536) assigned, in accordance with an act of 27 Henry VIII, to the bishops of Norwich.