William Litterer (1834–1917) was an American Democratic politician.

[1] His father, Charles A. Litterer, taught at Heidelberg University.

[1] Litterer worked as a maritime pilot on the Cumberland River.

[1] On February 10, 1891, he was elected Mayor, to complete the unexpired term of McCarver.

[1][3] In 1915, Litterer purchased the building of the University of Nashville Medical Department called the Litterer Laboratory (on the National Register of Historic Places since January 9, 1978) and donated it to Vanderbilt University.