He was the son of William Lowth, an apothecary, who was burnt out in the Great Fire of London, and was born in the parish of St Martin, Ludgate on 3 September 1660.
Simon Lowth, rector of Tilehurst, Berkshire, and was admitted to Merchant Taylors' School[1] on 11 September 1672.
He was elected scholar of St John's College, Oxford, on 11 June 1675, and in due course became Fellow.
[2] Early work brought him to the notice of Peter Mews, Bishop of Winchester, who made him his chaplain, gave him a prebendal stall at Winchester on 8 October 1696, and presented him to the benefice of Buriton with Petersfield, Hampshire, in 1699, which he held until his death.
[2] His first published work was a ‘Vindication of the Divine Authority of the Old and New Testaments,’ London, 1692, a defence of the inspiration of holy scripture against the attacks of Jean Le Clerc.