He owned and operated United Laboratories, Inc, a company principally engaged in research on lubricating processes for chemical products, war industries and biochemistry.
Also Malisoff, with Niels Bohr, Bertrand Russell, Ernest Nagel et al sat on the Advisory Committee of the International Encyclopedia of Unified Science.
According to Venona project information, the Soviets, in 1944, were having considerable trouble with Malisoff as he wanted sizable funds to help him establish a manufacturing capacity at New York laboratory (Reisch, 107).
In August 1943 Pavel Mikhailov, the New York Soviet Military Intelligence (GRU) Rezident sent an inquiry to Moscow regarding Malisoff.
William Marias Malisoff, whose cover name assigned by Soviet intelligence and deciphered by Arlington Hall cryptographers were HENRY and TALENT.