The William S. Moorhead Federal Building is a 340-foot (100 m)-tall skyscraper that is located in downtown Pittsburgh, Pennsylvania, United States.

Plans for the building were announced on November 9, 1958, and the structure was completed in 1964.

Designed by Altenhof & Bown, the building replaced an existing Greyhound bus station on the property.

[3] In 1980, the building, which accommodated 35 federal agencies at that time, was renamed the William S. Moorhead Federal Building, in honor of retiring Representative William S. Moorhead.

has 21 tenants, including the Internal Revenue Service, the Veterans Administration, the Army Corps of Engineers (formerly housed in the Manor Building), the Weather Bureau (formerly in the US Post Office and Courthouse), the Federal Bureau of Investigation (formerly in the Union Trust Building) and the Central Intelligence Agency (originally referred to as "Agency 39"), employing 4,000 employees.