The William S. Peirce School is a historic school building that is located in the Southwest Center City neighborhood of Philadelphia, Pennsylvania, United States.

Designed by Irwin T. Catharine and built between 1928 and 1929, it is a four-story, nine-bay, brick building that sits on a raised basement.

Created in the Late Gothic Revival-style, it features pilasters with limestone caps and a projecting entrance pavilion with an arched opening.

[2] This historic building opened in 1928 as a K-8 school, but elementary grades were dropped in 1988.

[3] It was added to the National Register of Historic Places in 1988.