He was also a Chaplain of the United States Senate and the first President of Columbian College from 1821-1827, which is the original name and oldest division (1821) of The George Washington University.
He also taught theological and classical courses at the college, including general history, belles lettres, rhetoric, moral philosophy and divinity, and pulpit eloquence.
After five years serving as president, Staughton resigned due to the college's financial troubles and dispute among the board of trustees regarding the theology and classic departments.
[1] In 1826, he was sent, along with Samuel Wait, future first president of Wake Forest University, to New Bern, North Carolina, to raise funds for the church.
He made literary contributions to The Latter Day Luminary and edited The Works of Virgil, as well as A Compendious System of Greek Grammar by Edward Wetenhall.