Sir William Trussell was an English politician and leading rebel in Queen Isabella and Roger Mortimer, 1st Earl of March's rebellion against Edward II.

As Edward II slowly regained power from the Ordainers he rewarded Hugh le Despenser, 1st Earl of Winchester with land confiscated from the barons, leading to a baronial revolt, which Trussell joined.

[4][non-primary source needed] The warrant was reissued in 1324 alongside similar ones that dealt with alleged rioting against Despenser in Warwickshire, Staffordshire, and Worcestershire by other rebels.

[4][non-primary source needed] Trussell fled to France and was not named as an accomplice of Zouch and the Folville Gang when they murdered/executed de Beler in January 1326, presumably in revenge for his enforcement on behalf of Despenser.

Trussell then joined up with Queen Isabella and Mortimer in Paris before moving to Flanders where he was allegedly tasked with helping to build an invasion army by William I, Count of Hainaut.